Senior Scientist QSP/T and PBP/TK (m/f/d)

esqLABS GmbH
  • Saterland, Germany
  • Other
  • Information Technology & Digital
  • English Only
  • 4-6 year
  • 15+ days ago
  • Saterland, Germany
  • Permanent-Full time
  • Other
  • Information Technology & Digital
  • English Only
  • 4-6 year
  • 15+ days ago

Permanent-Full time

Job Description

About the job
esqLABS is not only an innovative contract research organization for the pharmaceutical, chemical, and food industry specialized in PBP/TK and QSP/T, but also a member of the Open-Systems-Pharmacology (OSP) Management Team. We help drive the development and standards of the open domain software (PK-Sim® and MoBi®) within a cross-functional environment with academia and industry to push the boundaries of quantitative systems pharmacology and systems toxicology. esqLABS has gained considerable momentum, providing world-wide services and attracting international players in the pharma and crop industry but also start-ups in the life-science technology sector as clients. In addition, funding through national and EU-wide research grants allows us to progressively further the development of our core technologies.
To help us grow and lead our global PBPK business, we are looking for a Senior Scientist QSP/T and PBP/TK (m/f/d) to strengthen our team.

About Your New Role
Are you a highly talented and motivated life-science modeling & simulation scientist? Do you enjoy driving innovation and setting new boundaries in physiologically-based (PBK) modeling & quantitative systems pharmacology and toxicology (QSP/T)? Then this could be a good fit:
Scientific Methodology & Strategy development
Project management for client projects in our PBPK and/or QST business
Assess and define regulatory requirements and compile submission-ready reports
Support customer projects (Hands-on PBK / QSP/T model development)
Track use cases and communicate with peers to assess project requirements
Challenge (project) requirements and engineer feasible solutions from start till end

Skills & Experience We Require
5+ years of experience in applications of mechanistic modeling in toxicological risk assessment and/or pre-clinical and clinical development
5+ years of experience in leading modeling & simulation projects for clients
Advanced expertise in domain-specific modeling software (e.g. R / PK-Sim® / MoBi®, SimCyp®, or GastroPlus®)
Advanced expertise in a scripting language for modeling and simulation (ideally R, alternatively MATLAB®)
Profound knowledge of the toxicological risk assessment and/or drug discovery and development process
Profound knowledge of regulatory requirements and guidelines for PBP/TK and TD
Fluency in English (oral and written)

Skills & Experience That Are Nice To Have
Advanced expertise in pharmacometric modeling software (e.g. NONMEM®, Monolix, or IQRtools)
A strong understanding of statistics
Therapeutic/Toxicology domain knowledge: Developmental Neurotoxicity, Hepatotoxicity (or DILI), Nephrotoxicity (and/or diseases such as Diabetes, Oncology, Immunology or Inflammation)
Experience in regulatory submissions
Published peer-reviewed articles

What We Offer
A passionate and dedicated team with people who are always willing to broaden their horizon
Flexible work hours and a home office policy that focuses on people and not on numbers
An attractive remuneration package
A dedicated budget for education programs and conferences you can attend
A working environment in which your contribution will make the difference
Sounds like a fit? Then we are looking forward to receiving your application via click apply !
If you require any further information, feel free to contact Dr. Stephan Schaller on click apply.

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